This parallel viewing allows easier control of cells and enables switching between cells much faster. New in Clampex 11, users can now execute protocol-editor-style Epochs and program digital or analog outputs in Gap-free recording.
Clampex 11 Software—Flexible Data Acquisition Clampex 11 is built on the previous version 10, which already has a powerful built-in feature set. Enhancements include: Improved Protocol Editor—features up to 50 Epochs and 5X increase sweep duration Enhanced Gap-free mode—able to execute episodic-style epochs and program of digital and analog outputs Redesigned Membrane Test—enables viewing and individual controlling of multiple channels simultaneously in the same window.
Clampfit 11 Software—Smart Data Analysis Clampfit 11 Software offers a comprehensive palette of tools for data analysis. Highlights include: Up to 25 cursor pairs allow more selection for regions of interest Graph plotting tools such as I-V plot and histogram Data conditioning such as filtering and baseline adjustment Fitting and statistical analysis Event detection including Template Search, Threshold search, and Single-channel search.
Clampfit Advanced Analysis Module—Sophisticated Data Analysis This module is a set of tools that expand the capabilities of Clampfit to combine powerful analyses with ease-of-use. Highlights include: New Batch Data Analysis Tool—apply macros to analyze acquired data, thus saving time and reducing repetitive programming Improved Automated Event Detection—identify events based on user-defined parameters, which now includes populations spikes and paired pulses New Population Spike Analysis Tool—automatically calculates amplitude, area under the curve, coastline of spikes, etc.
Shop Now. Action Potential Analysis in Clampfit Module. The channels show a mean inward conductance with mM potassium in the pipette of 44 pS and an outward conductance of 23 pS.
The open probability is not voltage dependent, and the channels do not exhibit calcium dependence. The channels are quite different from others described in hepatocytes, but they show marked similarities to channels recently described in renal epithelial cells.
Current-voltage relationships in the whole cell mode exhibit an increase in slope conductance at large hyperpolarizing and depolarizing potentials. Continue Reading. Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today? Design advanced protocols easily The enhanced protocol editor enables up to 50 epochs instead of 10, providing the flexibility to program longer, more sophisticated protocols.
Click to View Demo. Comprehensive analysis tools The software includes a wealth of analysis tools including 24 cursor pairs for regions of interest search, graph plotting tools such as I-V plot and histogram, and more. Improved visualization The membrane testwindow displays up to eight channels simultaneously, making it easier to control multiple channels.
Enhanced gap-free mode A simple continuous "chart-recorder" useful for monitoring single channel events, minis, and other spontaneous activities. View Interactive Demo. View all Resources. View All. In addition to potentially playing a key role in learning and memory, it is also a target for re… Read Customer Breakthrough Read Customer Breakthrough.
Customer Breakthrough York University uses Axon Patch-Clamp instruments to investigate the roles of pannexin channels in epilepsy York University uses Axon Patch-Clamp instruments to investigate the roles of pannexin channels in epilepsy The Zoidl lab at York University, Canada, investigates the roles of pannexin channels in the nervous system in both physiological and pathological contexts, primarily using z… Read Customer Breakthrough Read Customer Breakthrough.
Download Brochure Download Brochure. Customer Breakthrough Allegheny College uses our Axon patch-clamp instruments to investigate how amyloid beta peptide block ion channels in Alzheimer's disease Allegheny College uses our Axon patch-clamp instruments to investigate how amyloid beta peptide block ion channels in Alzheimer's disease Dr.
Customer Breakthrough University of Texas uses the Axon Patch-Clamp Systems to evaluate signaling mechanisms in the brain underlying memory and recall University of Texas uses the Axon Patch-Clamp Systems to evaluate signaling mechanisms in the brain underlying memory and recall The goal of these studies is to identify mechanisms that are amenable to therapeutics and therefore applicable for preventing memory loss.
Dated: Jan 12, View less. Dated: Oct 01, Publication Name: Acta Physiologica Sinica. Dated: Jun 01, Publication Name: American Physiological Society. The patch-clamp technique has been used to investigate single-channel and whole cell conductances in freshly isolated rat hepatocytes. Clampfit: Segmented Average is working again - more than one sweep is processed.
Clampfit: Averaging or Concatenation works on High-Speed Oscilloscope files containing an averaged trace, by discarding the old average. Clampfit: Burst Analysis can now recognize the last event in the file as a burst. Clampfit: P open in Event Statistics corrected for individual traces. Clampfit: NP open in Event Statistics corrected for trace and search.
Clampfit: Event Statistics corrected for data sets not starting in trace 1. Clampfit: Results window analyses retain sheet tab changes. Clampfit: Define Graph in Event Detection allows selecting events without erasing of fitted curves.
Clampex: CyberAmp telegraphs are not read by AxoScope. Clampfit: Basic Statistics only processes the first selected column when "All selected columns" is used. Clampex: Online statistics for the first sweep of a trial are displayed.
Clampex: Analysis window left-clicking near the Y-axis spinners no longer changes the active sweep. Clampfit: Burst Analysis applies the correct times to single event bursts. Clampfit: Burst Analysis handles events longer than the burst delimiting interval.
Clampfit: Burst Analysis for custom single-channel data calculates correct timing using the "Time to first event" parameter. Clampfit: Concatenated or Average Files created with this version can be concatenated or averaged again. Clampfit: Concatenation of "Run averaged" episodic files keeps the correct scaling.
Clampfit: Tags are transferred during file concatenation. Clampfit: Concatenation or Average Files truncates resultant files to the maximum limit of 10, sweeps per file. Clampfit: Average Traces cannot calculate the standard deviation for a High-Speed Oscilloscope file acquired with averaging. Clampfit: Burst Analysis skips the last burst if it is composed of a single event. Clampex: Old split-clock "gear-shifted" protocol files can now be opened.
Clampex: Statistics filenames are again logged in the Lab Book. Clampex: Statistics files are again saved if acquisition is aborted. Clampfit: Data reduction no longer shifts tags to the left.
Clampfit: Fitting with multiple fixed seed values now keeps seed values. Clampfit: Exponential probability fitting with a Variable Metric search method now works.
Clampex: Online statistics for single-sweep runs do not update. Clampex: The presweep post-train holding level does not apply to the sweep's first holding level. Clampfit: Concatenating averaged sweeps increases their Y-axis scaling x Clampfit: Data files with voice tags will not preserve these tags if the files are resaved to the ABF integer format. Clampfit: Layout files from Clampfit 8 open very slowly and have a black background.
Clampfit: Write Cursors measurements time columns now correctly labeled in milliseconds, instead of seconds. Clampfit: Custom function fitting parameters "fixed" values now remain constant during fitting.
Clampfit: Burst Analysis single openings no longer reported as double the actual duration. Changes Clampfit: ABF files with more than tags now prompt the user to disable tags to speed up file opening.
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